The most accurate choice is: "European colonizers in the Americas, on the whole, treated Indigenous people with cruelty. These practices led Indigenous people to fight back. Examples of this include the Pueblo Rebellion and the fight of the Iroquois Confederacy against the Americans in the Revolutionary War."
This statement acknowledges the harsh treatment Indigenous populations endured at the hands of European colonizers, while also highlighting the resistance movements that arose in response to such treatment. The Pueblo Rebellion of 1680 and the involvement of the Iroquois Confederacy during the Revolutionary War are significant historical examples of Indigenous resistance, showcasing the resilience and agency of these communities in the face of oppression.