The correct answer is:
D. Fermentation can occur without oxygen.
While aerobic respiration requires oxygen to efficiently produce ATP, fermentation allows cells to generate energy in the absence of oxygen, albeit less efficiently than aerobic respiration. The other options are not correct because:
A. Fermentation typically requires glucose or other carbohydrates as a substrate. B. Fermentation usually produces waste products (like lactic acid or alcohol). C. Fermentation produces significantly less ATP per glucose molecule compared to aerobic respiration.