To simplify the expression
\[ \frac{150x^8y^4}{25x^6y^3}, \]
we can start by simplifying the coefficients and then the variables.
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Coefficients:
\[ \frac{150}{25} = 6. \]
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Variables:
For \(x\): \[ \frac{x^8}{x^6} = x^{8-6} = x^2. \]
For \(y\): \[ \frac{y^4}{y^3} = y^{4-3} = y^1 = y. \]
Now, combining these results, we get:
\[ 6x^2y. \]
Thus, the simplified expression is:
\[ 6x^2y. \]
From the provided multiple choice answers, it looks like the answer \(6x^2y\) is optioned, so that is the correct choice.