The correct explanation of the relationship between wheat and its early hearth of domestication is:
Option E: "Wheat was first domesticated in Mesopotamia because of a favorable climate and a great diversity of wild grains that led to crossbreeding of seeds."
This option accurately reflects the historical understanding that wheat was domesticated in the Fertile Crescent region, specifically in places like Mesopotamia, where the environmental conditions were conducive to agriculture and allowed for the development and domestication of various wild grain species.