The most accurate statement regarding natural selection from the given options is:
Natural selection cannot inactivate genes.
The other statements are incorrect for the following reasons:
- Natural selection can influence reproduction rates by favoring traits that enhance reproductive success.
- Natural selection can change the frequency of alleles in a population over time, even if it does not change the alleles an organism has.
- Natural selection can occur in response to mutations, as mutations can provide new traits that may be subject to natural selection.
So, the correct choice is that natural selection cannot inactivate genes.