The accurate descriptions of the African slave trade of the 1500s among the responses provided are:
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During the 1500s, African slave traders began to sell slaves for the Americas rather than for Muslim lands to the north and east. - This statement reflects the shift in focus towards the transatlantic slave trade.
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The Portuguese and Spanish were the first Europeans to seek African slaves to work in their colonies. - This statement is correct, as the Portuguese were among the first to engage in the African slave trade, followed by the Spanish.
The other statements are not accurate:
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Slavery first began in Africa in the 1500s and then spread to other parts of the world in what became known as the Middle Passage. - Slavery existed in Africa long before the 1500s, and the Middle Passage specifically refers to the transatlantic journey of enslaved Africans to the Americas.
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African slavers refused to sell other Africans into slavery outside of Africa. - This statement is inaccurate, as African leaders and traders participated in the slave trade, selling captured individuals to European traders for transport to the Americas and elsewhere.