D It provided a faster means to access previously isolated regions.
The construction of the Transcontinental Railroad significantly contributed to the end of the American frontier by facilitating faster and more efficient transportation of people and goods. This led to increased settlement of previously isolated areas, development of towns and cities, and a more integrated national economy. As the railroad connected the East and West Coasts, it diminished the sense of a vast, untamed frontier, ultimately contributing to the transformation and development of the American West.