The correct responses regarding the events in the Spanish Conquest of the Aztec Empire are:
- Malinche helped the Spanish ally with Aztec enemies.
- A battle broke out between the Aztecs and the Spanish in which Moctezuma was killed.
- Caribbean colonies were used as a base to conquer the mainland.
The statement "The Aztecs successfully defended Tenochtitlán from Spanish invaders" is incorrect, as Tenochtitlán ultimately fell to the Spanish in 1521.