If there were no uplift on Earth, the most significant difference would be D. No Mountains. Uplift is a geological process that causes the Earth's surface to rise, leading to the formation of mountains and other elevated landforms. Without this process, we would likely see a much flatter landscape with fewer dramatic topographical features.
While the absence of uplift could also influence the presence of rivers and glaciers, it's important to note that rivers can exist through processes other than uplift, such as erosion and sediment deposition. Glaciers can form in cold climates regardless of uplift, and beaches can still exist along coastlines without mountains. However, mountains are primarily a result of uplift, making option D the most directly impacted.