The main difference between Magellan's voyage and Columbus's is that Magellan's expedition was the first to circumnavigate the globe, while Columbus's voyages aimed primarily to find a westward route to Asia by crossing the Atlantic. To address your options:
- Magellan did not sail west across the Atlantic to reach the Caribbean.
- Magellan's voyage did indeed involve sailing south down the coast of South America to find a passage to the Pacific, specifically the Strait of Magellan.
- Magellan did not sail east around Africa; that was part of Vasco da Gama's route to India.
Therefore, the correct response that differentiates Magellan's voyage would be that Magellan sailed south down the coast of South America in search of a passage to the Pacific Ocean.