To determine the type of mutation that has occurred, we would typically need to assess the specific changes in the DNA sequence outlined in the diagram you mentioned. However, without the diagram to reference, I can provide a brief description of each type of mutation:
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Deletion: A nucleotide is lost from the DNA sequence. This can lead to a shift in the reading frame if the number of nucleotides deleted is not a multiple of three.
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Frameshift: Occurs when nucleotides are inserted or deleted from the sequence, causing a shift in how the sequence is read. This change alters the reading frame of the codons following the mutation.
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Insertion: One or more nucleotides are added to the DNA sequence. Like deletion, this can cause a frameshift if the insertion number is not a multiple of three.
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Substitution: One nucleotide is replaced by another. This type of mutation may or may not affect the amino acid sequence, depending on whether it leads to a silent, missense, or nonsense mutation.
If the disorder is a result of a shift in the reading frame or a significant change in the translation of the DNA sequence, it is likely a frameshift mutation. If only one nucleotide was changed without affecting the frame, it would be a substitution.
From the options you’ve provided, if it specifically relates to a significant alteration in protein translation, the most likely response would be frameshift. If you are referring to a specific change without further details or context about the disorder in question, I recommend checking the diagram for the exact nature of the mutation.