The first-line treatment for syphilis, regardless of the patient's gender, is typically benzathine penicillin G. The specific regimen may vary based on the stage of syphilis:
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Primary, Secondary, and Early Latent Syphilis: 2.4 million units of benzathine penicillin G administered as a single intramuscular injection.
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Late Latent Syphilis or Syphilis of Unknown Duration: 2.4 million units administered as three doses of benzathine penicillin G (2.4 million units each) given at week intervals.
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Neurosyphilis: A different regimen involving aqueous crystalline penicillin G or procaine penicillin is typically used.
It's important for individuals to consult healthcare professionals for proper diagnosis and treatment, as individual cases may vary.