If you twisted your ankle while running, the most likely need would be "la rodilla" (the knee), as you may need support to stabilize your ankle. However, considering the options given, "una silla de ruedas" (a wheelchair) could also be relevant if you are unable to walk.
But typically, "la rodilla" is not directly related to an ankle injury, so the best practical response given your specific situation of a twisted ankle would be to seek rest, ice, compression, and elevation, rather than needing a physical object from the options provided. In this context, a more appropriate option was not provided.
So, if I had to choose strictly from your options and interpreting the list literally, "una silla de ruedas" could allow mobile support if the injury is severe.