The most accurate answer to the question of how economics contributed to shifting attitudes toward slavery in Georgia between 1750 and 1860 is:
D. Georgia's economic reliance on slavery in cotton production led people to try to normalize and defend it.
This is because the economy of Georgia, much like other Southern states, became heavily reliant on the plantation system and the production of cotton, which was a labor-intensive crop that depended on enslaved labor. As the cotton industry flourished, attitudes toward slavery largely shifted to normalize and defend the institution, as it was seen as essential to the state's economic prosperity.