The deviation of a data point in relation to the mean is calculated as:
\[ \text{Deviation} = \text{Data Point} - \text{Mean} \]
Given that the mean of the dataset is 59 and the data point in question is 43, we can calculate the deviation as follows:
\[ \text{Deviation} = 43 - 59 = -16 \]
Therefore, the correct response is:
−16