The two consequences of westward expansion on native tribes are:
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Depletion of food supply - As settlers expanded westward, they often hunted buffalo and other game to near extinction, disrupting the food sources that many Native tribes relied upon for their survival.
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Disease - Westward expansion brought settlers and soldiers into contact with Native tribes, leading to the spread of diseases like smallpox, influenza, and measles, which devastated Native populations who had no immunity to these illnesses.