The most appropriate question to ask this person in Spanish, assuming you want to inquire about their state of fatigue, would be:
¿Estás cansada? (if the person is female) or ¿Estás cansado? (if the person is male).
Given the options, the correct response would be:
¿Estás cansada? (if addressing a female) or ¿Estás cansado? (if addressing a male).
If you are unsure of the person's gender, it’s safer to stick to neutral inquiries or use a broader context. However, based on the responses provided, the first option would be correct if the person is female.