To simplify the expression \((53x + 82y) - (-38x + 4y)\), we first distribute the negative sign across the terms inside the parentheses:
\[ (53x + 82y) + (38x - 4y) \]
Now, we can combine like terms:
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Combine the \(x\) terms: \[ 53x + 38x = 91x \]
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Combine the \(y\) terms: \[ 82y - 4y = 78y \]
Putting it all together, we get:
\[ 91x + 78y \]
Thus, the simplified expression is:
\[ \boxed{91x + 78y} \]