The statements that accurately describe the toll of the Middle Passage are:
- Two million slaves may have died of disease and mistreatment as they crossed the Atlantic.
- It involved the mistreatment of millions of slaves captured over the course of 300 years.
The other statements are not accurate in the context of the Middle Passage. While European traders did transport sugar and tobacco to the Americas, the focus of the question is on the toll of the Middle Passage itself. Additionally, the statement regarding more slaves being transported to the Middle East than to the Americas is misleading; the transatlantic slave trade primarily involved the shipping of enslaved people to the Americas.