To calculate the commission from a sale, you can use the formula:
\[ \text{Commission} = \text{Sale Amount} \times \text{Commission Rate} \]
In this case, the sale amount is $350 and the commission rate is 6% (or 0.06 in decimal form).
\[ \text{Commission} = 350 \times 0.06 = 21 \]
Therefore, the commission from the sale of $350 worth of clothing is $21.