Hamilton and Jefferson had significant disagreements on the following issues:
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The role of the federal government: Hamilton favored a strong central government, while Jefferson advocated for more power to the states and a limited federal government.
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How to structure a banking system: Hamilton supported the establishment of a national bank and a strong financial system, whereas Jefferson was opposed to a national bank, fearing it would concentrate too much power in the hands of the federal government.
These two issues were at the heart of their differing philosophies regarding governance and economics in the early United States.