To find \( f(-4) \) for the function \( f(x) = (x^8)^2 \), we first substitute \( -4 \) into the function.
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Calculate \( (-4)^8 \): \[ (-4)^8 = 65536 \] (Since raising to an even power results in a positive value.)
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Now square \( 65536 \): \[ f(-4) = (65536)^2 \]
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Calculate \( 65536^2 \): \[ 65536^2 = 4294967296 \]
Thus, \[ f(-4) = 4294967296 \]
So the final answer is: \[ \boxed{4294967296} \]