Question
How do cancer cells have increased cell division?
Increased transcription factor activity
Decreased transcription factor activity
Increased transcription factor activity
Decreased transcription factor activity
Answers
GPT-4o mini
Cancer cells typically exhibit increased cell division due to a combination of genetic mutations and abnormal regulation of cellular processes. One primary mechanism behind this increased proliferation is the altered activity of transcription factors.
1. **Increased Transcription Factor Activity**: Many cancer cells have mutations that lead to the overexpression or constitutive activation of transcription factors that promote cell cycle progression and survival. For example, oncogenes can encode for transcription factors that drive the expression of genes necessary for cell division. When these transcription factors are overactive, they can lead to the continuous proliferation of cells, bypassing the normal regulatory mechanisms that restrict cell division.
2. **Decreased Transcription Factor Activity**: While decreased activity of certain transcription factors can also contribute to cancer (for example, tumor suppressor gene products that normally inhibit cell division), in the context of increased cell division, it is generally the increased activity of pro-proliferative transcription factors that is more directly responsible for the unchecked growth characteristic of cancer.
In summary, cancer cells primarily exhibit increased cell division due to **increased transcription factor activity** that promotes cell proliferation and survival.
1. **Increased Transcription Factor Activity**: Many cancer cells have mutations that lead to the overexpression or constitutive activation of transcription factors that promote cell cycle progression and survival. For example, oncogenes can encode for transcription factors that drive the expression of genes necessary for cell division. When these transcription factors are overactive, they can lead to the continuous proliferation of cells, bypassing the normal regulatory mechanisms that restrict cell division.
2. **Decreased Transcription Factor Activity**: While decreased activity of certain transcription factors can also contribute to cancer (for example, tumor suppressor gene products that normally inhibit cell division), in the context of increased cell division, it is generally the increased activity of pro-proliferative transcription factors that is more directly responsible for the unchecked growth characteristic of cancer.
In summary, cancer cells primarily exhibit increased cell division due to **increased transcription factor activity** that promotes cell proliferation and survival.