Hamilton and Jefferson had significant disagreements on various issues. The main issues on which they disagreed included:
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The role of the federal government - Hamilton favored a strong central government, while Jefferson advocated for more power to the states.
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How to structure a banking system - Hamilton supported the creation of a national bank, while Jefferson opposed it, fearing it would centralize too much power.
Other issues such as imposition of taxes and how to structure the judiciary were also areas of contention, but the primary distinctions were in the roles of government and banking.
Given your instruction to "pick one of 4," you can select one. However, based on the most prominent disagreements, I would recommend "the role of the federal government" as a key point of contention.