In Hamlet, I don't understand what the Queen mean when she says “To my sick soul…/ Each toy seems prologue to some great amiss”?

Answer 1

According to Sparknotes, that passage means:

"(to herself) To my sick soul (since sin is always a sickness), every detail looks like an omen of disaster to come."

I don't have the text in front of me and I am not a Shakespeare expert, but you can either trust what Sparknotes tells you or you can continue analyzing it for yourself.