In prokaryotes, gene expression is primarily controlled by regulatory sequences in the DNA, such as promoters and operators, which interact with proteins like transcription factors and repressors. Additionally, operons, which are clusters of genes under the control of a single promoter, allow for coordinated regulation of related genes in response to environmental changes.

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In prokaryotes, gene expression is predominantly regulated through DNA regulatory sequences like promoters and operators that interact with transcription factors and repressors, and is efficiently coordinated by operons, which are clusters of genes controlled by a single promoter, enabling a unified response to environmental changes.