Simplify 6(3q−4)+18−12q−7(4q+5)

To simplify the expression \( 6(3q - 4) + 18 - 12q - 7(4q + 5) \), we'll follow the order of operations:

1. Distribute the terms:
   • \( 6(3q - 4) = 18q - 24 \)
   • \( -7(4q + 5) = -28q - 35 \)

Now we substitute these back into the expression:

\[ 18q - 24 + 18 - 12q - 28q - 35 \]

2. Combine like terms:
   • For the \( q \) terms: \( 18q - 12q - 28q = (18 - 12 - 28)q = -22q \)
   • For the constant terms: \( -24 + 18 - 35 = -24 + 18 - 35 = -41 \)

Putting it all together, we get:

\[ -22q - 41 \]

Thus, the simplified expression is:

\[ \boxed{-22q - 41} \]