The two features that most strongly link the Spanish to Venezuela, Ecuador, and Colombia during the 1500s are:
A. Potential for mining of gold - The Spanish were highly motivated by the prospect of mineral wealth, particularly gold, which led them to explore and colonize regions rich in these resources.
B. Varied climates for multiplied crops - The varied climates of the Andean region allowed for the cultivation of a diverse range of crops, which was attractive to the Spanish for both sustenance and trade.
These factors were significant in encouraging Spanish colonization and exploitation in these areas compared to other regions.