Among the options listed, fossil fuel combustion causes the greatest depletion of oxygen from the atmosphere. While all the processes mentioned consume oxygen, fossil fuel combustion typically occurs on a much larger scale due to industrial activities, transportation, and energy generation. This results in significant amounts of oxygen being consumed as hydrocarbons are burned to release energy.
Respiration of air-breathing organisms also consumes oxygen, but its scale is relatively smaller compared to the immense volumes involved in fossil fuel combustion. Weathering and oxidation, as well as decay and bacteria, also consume oxygen but have less impact overall compared to the scale of fossil fuel use.