The main difference between a presidential system and a parliamentary system of government is:
The chief executive of the presidential system is separate from the legislature, but the chief executive of the parliamentary system is usually a member of the legislature.
In a presidential system, the president is elected independently of the legislative body and holds significant powers, while in a parliamentary system, the prime minister is typically chosen from the legislative branch and is accountable to it, meaning they can be removed by a vote of no confidence from the legislature.