To simplify the expression \( 2^4 \cdot 2^2 \) using the Product Rule of Exponents, we can apply the rule that states \( a^m \cdot a^n = a^{m+n} \).
For your expression, we have:
\[ 2^4 \cdot 2^2 = 2^{4+2} = 2^6 \]
So, the simplified expression is:
\[ 2^6 \]