Benzene, a by-product found in cigarettes, is primarily associated with increased risks of cancer. In particular, it has been linked to leukemia and other blood cancers. Among the options provided, the most relevant and significant concern in relation to benzene exposure would be:
miscarriage.
While benzene is associated with various health issues, including the risk of cancer, the context of this question suggests a focus on risks more directly linked to benzene rather than general effects of smoking like chronic bronchitis or susceptibility to infections.