The best summary of how Columbus's and Vasco da Gama's motivations differed would be:
C. Both had three motivating factors; however, Columbus achieved spices, God, and glory whereas da Gama achieved glory and silk.
Columbus was motivated by a combination of seeking new trade routes (including spices), spreading Christianity (God), and gaining glory through exploration, while Vasco da Gama is primarily noted for his successful exploration that established a sea route to India, focusing on trade (including silk and spices) and gaining glory for Portugal.