Question
cystic fibrosis is an inherited disorder that is caused when bases are accidentlly removed form the cftr gene. which of the following is true about cystic fibrosis
Answers
GPT-4o mini
Cystic fibrosis (CF) is indeed an inherited disorder caused by mutations in the CFTR gene (cystic fibrosis transmembrane conductance regulator), which is located on chromosome 7. The most common mutation responsible for CF is a deletion of three bases in the CFTR gene, leading to the absence of a phenylalanine amino acid at position 508 (F508del mutation). However, cystic fibrosis can result from a variety of mutations, not just base deletions.
Here are some true statements about cystic fibrosis:
1. **Inheritance Pattern**: Cystic fibrosis is inherited in an autosomal recessive manner. This means that a person must inherit two mutated copies of the CFTR gene (one from each parent) to develop the disease.
2. **Effects on Organs**: CF primarily affects the lungs and digestive system. It causes the production of thick, sticky mucus that can clog the airways and lead to respiratory infections. It can also obstruct the pancreatic ducts, affecting digestion and nutrient absorption.
3. **Symptoms**: Common symptoms of cystic fibrosis include persistent cough, excessive sputum production, recurrent lung infections, difficulty breathing, poor growth, and difficulty gaining weight.
4. **Diagnosis**: Cystic fibrosis is commonly diagnosed through a sweat test, which measures the concentration of salt in sweat, and genetic testing to identify mutations in the CFTR gene.
5. **Management and Treatment**: While there is no cure for cystic fibrosis, treatments are available to manage symptoms and improve quality of life. These may include mucolytics, pancreatic enzyme supplements, antibiotics, and therapies to improve lung function.
If you have more specific statements or options to evaluate, feel free to share them!
Here are some true statements about cystic fibrosis:
1. **Inheritance Pattern**: Cystic fibrosis is inherited in an autosomal recessive manner. This means that a person must inherit two mutated copies of the CFTR gene (one from each parent) to develop the disease.
2. **Effects on Organs**: CF primarily affects the lungs and digestive system. It causes the production of thick, sticky mucus that can clog the airways and lead to respiratory infections. It can also obstruct the pancreatic ducts, affecting digestion and nutrient absorption.
3. **Symptoms**: Common symptoms of cystic fibrosis include persistent cough, excessive sputum production, recurrent lung infections, difficulty breathing, poor growth, and difficulty gaining weight.
4. **Diagnosis**: Cystic fibrosis is commonly diagnosed through a sweat test, which measures the concentration of salt in sweat, and genetic testing to identify mutations in the CFTR gene.
5. **Management and Treatment**: While there is no cure for cystic fibrosis, treatments are available to manage symptoms and improve quality of life. These may include mucolytics, pancreatic enzyme supplements, antibiotics, and therapies to improve lung function.
If you have more specific statements or options to evaluate, feel free to share them!
1 cystic fibrosis is caused by a deletion mutation.
2. it is not known why cystic fibrosis happens in people.
3. cystic fibrosis is a silent disorderd, it has no symptoms.
4. the affects of cystic fibrosis only impact women
2. it is not known why cystic fibrosis happens in people.
3. cystic fibrosis is a silent disorderd, it has no symptoms.
4. the affects of cystic fibrosis only impact women
GPT-4o mini
Let's evaluate each statement you provided about cystic fibrosis:
1. **Cystic fibrosis is caused by a deletion mutation.**
- **Partially True**: While one of the most common mutations associated with cystic fibrosis is a deletion of three nucleotides in the CFTR gene (specifically the F508del mutation), cystic fibrosis can be caused by a variety of mutations in the CFTR gene, including point mutations, insertions, and other deletions. Therefore, it's more accurate to say that cystic fibrosis can be caused by a deletion mutation rather than stating it is solely caused by one.
2. **It is not known why cystic fibrosis happens in people.**
- **False**: Cystic fibrosis is a well understood genetic disorder caused by mutations in the CFTR gene. The specific mutations and their mechanisms are known, and the condition is inherited in an autosomal recessive manner.
3. **Cystic fibrosis is a silent disorder; it has no symptoms.**
- **False**: Cystic fibrosis is not a silent disorder. It is characterized by a range of significant symptoms affecting the respiratory and digestive systems, such as chronic cough, frequent lung infections, and issues related to nutrient absorption due to pancreatic dysfunction.
4. **The effects of cystic fibrosis only impact women.**
- **False**: Cystic fibrosis affects both males and females equally. It is not gender-specific, and the symptoms and severity of the disease can vary in individuals regardless of their sex.
In summary, statements 2, 3, and 4 are false, while statement 1 is partially true but needs clarification to convey a more accurate picture of the genetic basis of cystic fibrosis.
1. **Cystic fibrosis is caused by a deletion mutation.**
- **Partially True**: While one of the most common mutations associated with cystic fibrosis is a deletion of three nucleotides in the CFTR gene (specifically the F508del mutation), cystic fibrosis can be caused by a variety of mutations in the CFTR gene, including point mutations, insertions, and other deletions. Therefore, it's more accurate to say that cystic fibrosis can be caused by a deletion mutation rather than stating it is solely caused by one.
2. **It is not known why cystic fibrosis happens in people.**
- **False**: Cystic fibrosis is a well understood genetic disorder caused by mutations in the CFTR gene. The specific mutations and their mechanisms are known, and the condition is inherited in an autosomal recessive manner.
3. **Cystic fibrosis is a silent disorder; it has no symptoms.**
- **False**: Cystic fibrosis is not a silent disorder. It is characterized by a range of significant symptoms affecting the respiratory and digestive systems, such as chronic cough, frequent lung infections, and issues related to nutrient absorption due to pancreatic dysfunction.
4. **The effects of cystic fibrosis only impact women.**
- **False**: Cystic fibrosis affects both males and females equally. It is not gender-specific, and the symptoms and severity of the disease can vary in individuals regardless of their sex.
In summary, statements 2, 3, and 4 are false, while statement 1 is partially true but needs clarification to convey a more accurate picture of the genetic basis of cystic fibrosis.