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The most likely way in which anti-poverty non-governmental organizations (NGOs) like Oxfam could help South America address political challenges is:
**D) Ending poverty could reduce political instability and corruption.**
By addressing poverty, NGOs can help create more stable and equitable societies, which can mitigate factors that contribute to political instability and corruption. Reducing poverty can empower individuals and communities, fostering a more engaged citizenry that is less susceptible to corrupt practices.