The correct statement about genetic material is:
Chromosomes are made up of genes.
Here's a brief explanation for the other statements:
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Chromatids contain chromosomes: This is incorrect. Chromatids are the two identical halves of a duplicated chromosome, not separate chromosomes themselves.
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Centromeres connect two chromosomes: This is incorrect. Centromeres are the region of a chromosome where two sister chromatids are joined, not two separate chromosomes.
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Genes encode deoxyribonucleic acid: This is misleading. Genes are segments of deoxyribonucleic acid (DNA) that contain the instructions for making proteins, but they don't encode DNA itself; DNA is the medium in which genes are found.
Thus, the most accurate statement is that chromosomes are made up of genes.