The Great Debate between the Federalists and Anti-Federalists significantly shaped the trajectory of American governance and political identity. Among the options you've provided, the most impactful response is:
Americans recognized that the Constitution was a document that could be modified when necessary.
This recognition paved the way for the adoption of the Bill of Rights, which was seen as a crucial compromise to ensure protections of individual liberties and to address the concerns raised by the Anti-Federalists about potential government overreach and tyranny. The debates highlighted the need for a flexible framework that could adapt to the evolving needs of the nation, leading to the understanding that amendments were not only necessary but a foundational aspect of the Constitution's durability. This idea of adaptability has played a critical role in American political life and has allowed the Constitution to endure for over two centuries.
While it's true that the debates caused divisions and highlighted differing visions of government, the eventual recognition that the Constitution could be amended provided a unifying solution that helped to stabilize the new government structure in a way that could accommodate ongoing discourse and dissent.