To solve the quadratic equation \( x^2 - 16x + 64 = 0 \) using the perfect square trinomial pattern, we can recognize that the left side can be written as a square of a binomial.
The expression \( x^2 - 16x + 64 \) can be factored as:
\[ (x - 8)^2 = 0 \]
Setting this equal to zero gives us:
\[ (x - 8)^2 = 0 \]
Taking the square root of both sides, we find:
\[ x - 8 = 0 \]
Solving for \( x \), we get:
\[ x = 8 \]
Thus, the solution to the equation is:
\[ \boxed{8} \]