According to Bartolomé de las Casas, a Spanish Dominican friar and missionary who advocated for the rights of Indigenous peoples, the Spanish treated American Indians in the Caribbean, particularly through the use of harsh and exploitative systems. The most accurate option based on his accounts would be:
C) they enslaved both men and women and let most die from overwork and starvation.
Las Casas documented the severe mistreatment of Indigenous populations, including their enslavement and the resulting high mortality rates from overwork and poor living conditions.