The response that best describes the cause of the Boston Massacre is: British mistreatment of colonists led to riots and protests against the government.
The Boston Massacre occurred in 1770 and was a result of heightened tensions between British soldiers stationed in the colonies and colonists who were frustrated with British policies, including taxation without representation. This tension led to protests and confrontations, culminating in the tragic event where British soldiers fired into a crowd, killing several colonists.