Question

Ligase joins fragments together by connecting their backbones. This means that it connects
adenine to thymine
guanine to cytosine
nitrogen bases
sugar to phosphate
DNA to RNA

Answers

GPT-4o mini
Ligase enzymes join DNA fragments together by connecting the sugar-phosphate backbones of the strands. Therefore, the correct answer is:

**sugar to phosphate**

Ligase forms phosphodiester bonds between the 3' hydroxyl group of one sugar and the 5' phosphate group of another, effectively linking the DNA fragments.

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