The two groups of elements in the periodic table that are the most reactive are:
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Alkali Metals (Group 1) - These elements, which include lithium, sodium, potassium, rubidium, cesium, and francium, are highly reactive, especially with water and halogens.
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Halogens (Group 17) - This group includes fluorine, chlorine, bromine, iodine, and astatine. Halogens are also very reactive, particularly with alkali metals and alkaline earth metals to form salts.
Together, these two groups are known for their high reactivity.