A manuscript is typically defined as a book or document that is written by hand, particularly before the invention of printing technology. In historical contexts, manuscripts were often created by scribes and could include literary works, religious texts, or other important documents. While the term can also refer to a draft or original version of a work (such as a novel or academic paper), it primarily denotes the handwritten nature of the document.
Therefore, the most relevant response from your list would be:
- a book that is written by hand.