The statement that best explains the Fourth Amendment’s protections against unreasonable searches and seizures is: "Law enforcement must have a search warrant and/or probable cause to search a person’s property."
This statement accurately reflects the general requirements established by the Fourth Amendment, which protects against unreasonable searches and seizures and typically requires law enforcement to have probable cause and, in many cases, a warrant to conduct searches. While there are specific exceptions (such as in schools with a lower standard of "reasonable suspicion"), the statement about law enforcement needing probable cause and/or a search warrant captures the core principle of Fourth Amendment protections.