The key difference between helium and the other elements in group 18 (the noble gases) is:
Helium atoms have 2 valence electrons, while atoms of the other elements in the group all have 8 valence electrons.
This is the correct statement, as helium is unique in that it has a complete outer shell with just 2 electrons, while other noble gases like neon, argon, and xenon have full outer shells with 8 electrons.