The correct comparison between prokaryotic and eukaryotic chromosomes from the provided options is:
Prokaryotes tend to only have one chromosome while eukaryotes have many.
Here’s a brief explanation of why the other choices are incorrect:
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Prokaryotic chromosomes are typically much larger than eukaryotic ones. (Incorrect: Eukaryotic chromosomes are generally larger than prokaryotic chromosomes.)
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Prokaryotic chromosomes are wrapped into structures called nucleosomes. (Incorrect: Eukaryotic chromosomes are wrapped around nucleosomes, while prokaryotic DNA does not form nucleosomes.)
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Prokaryotic chromosomes are linear while eukaryotic chromosomes are circular. (Incorrect: Prokaryotic chromosomes are typically circular, whereas eukaryotic chromosomes are linear.)
So the third choice about the number of chromosomes is the correct answer.