To find the best estimate for the product of \( 281 \times 2.16 \), we can round both numbers to make calculations easier.
- Rounding \( 281 \) gives us \( 300 \).
- Rounding \( 2.16 \) gives us \( 2 \).
So, the best estimation based on these rounded values is:
\[ 300 \times 2 \]
Therefore, the answer is:
300 × 2