The statement that accurately compares and contrasts eukaryotes and prokaryotes is:
Eukaryotes have a true nucleus and membrane-bound organelles, while prokaryotes lack a true nucleus and organelles.
This statement correctly reflects the fundamental differences between the two types of cells: eukaryotes have a well-defined nucleus and organelles enclosed by membranes, while prokaryotes do not have a true nucleus and typically lack membrane-bound organelles.