To provide the best translation of the instructions in the image, you would need to ensure clarity and conciseness. The most effective translation will depend on the context and the intended audience.
However, if I were to assess the options provided:
A. "Shake the bottle thoroughly" - Clear and straightforward. B. "First push down and then turn" - Indicates a specific sequence of actions. C. "Take one pill now and two later" - Provides a dosage schedule. D. "Set the bottle down then rotate it" - Instructs on how to handle the bottle.
Without seeing the image, I would suggest A ("Shake the bottle thoroughly") as it is a clear instruction that does not require additional context. But if the instructions are more specific to dosage or preparation, such as regarding medication, C might be even more appropriate.
Ultimately, the best choice would depend on the specific content of the image you refer to. If you provide more context about the image, I can help refine the answer!