To simplify the expression \((-2)(-2)(-2)(-2)\), we can group the terms:
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First, multiply the first two factors: \((-2)(-2) = 4\).
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Then, multiply the next two factors: \((-2)(-2) = 4\).
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Now, multiply the results of the two pairs: \(4 \times 4 = 16\).
Thus, \((-2)(-2)(-2)(-2) = 16\).
The correct response is: B 16.